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Drug Screening System for Cardioprotection
Application
A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity.
Key Benefits
A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol.
Preliminary data in the laboratory show the system is clinically relevant...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
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Indolium 1 for Advanced Melanoma Treatment
Application
A small molecule compound for the treatment of melanoma.
Key Benefits
Novel small molecule compound for the treatment of resistant melanoma.
Well tolerated in vivo.
Market Summary
Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Jack Arbiser
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Small Molecules as Disinfectants and Antiseptics
Application
Anti-microbial molecules with broad spectrum activities.
Key Benefits
Effective antimicrobial scaffolds with improved broad-spectrum activities compared to current commercial disinfectants.
Market Summary
There is an increased effort in developing new antibiotics, antiseptics, and disinfectants to overcome the current resistance...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): William (Bill) Wuest, Kevin Minbiole
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Small Molecule Compound to Treat Neurological Diseases
Application
NMDAR agents for the treatment of various neurological diseases.
Key Benefits
Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs.
The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility.
The initial studies have determined...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application
Small molecules to treat cystic fibrosis and other pulmonary diseases.
Key Benefits
Rescue rare variants of CFTR gene.
Serve as PDE4 inhibitors with strong anti-inflammatory effects.
Market Summary
Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
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Drug Combination to Treat Lung Cancer Metastasis
Application
Combination product co-targeting PDH and GLUT1 to inhibit lung cancer metastasis.
Key Benefits
Combination of drugs exhibits greater synergism in cancer cell lines (H1299, 4T1, H1792).
Has potential to prevent metastasis in a variety of cancers.
Decreases both cell viability and invasive area.
Repurposed drugs.
Market Summary
Metastatic...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Malathy (Mala) Shanmugam, Adam Marcus
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Small Molecule for Treatment-Resistant Lung Cancer
Application
Small molecule agonist for treating cancers involving KRAS mutations.
Key Benefits
Specifically targets mutant KRAS in non-small-cell lung carcinoma (NSCLC).
Selective for mutant KRAS lung cancer cells over normal cells.
Non-toxic to normal cells.
Market Summary
Lung cancer patients with KRAS mutation(s) have a poor prognosis due...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Xingming Deng
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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Hyunsuk Shim, Yoon Hyeun Oum
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Alexidine and Analogs to Treat Lung Cancer
Application
Small molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer.
Key Benefits
Inhibits cancer cell invasion.
Utilizes a novel mechanism of action.
Market Summary
One of the main barriers in developing new treatment strategies is the vast diversity between and within cancers. The cells within...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
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Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application
Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population.
Key Benefits
Significantly improved protective immunity of vaccine in the aged.
More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Elena Vassilieva, Richard Compans
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