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Drug Screening System for Cardioprotection
Application
A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity.
Key Benefits
A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol.
Preliminary data in the laboratory show the system is clinically relevant...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
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Tension-activated Cell Tagging (TaCT)
Application
A tool that measures cellular mechanical forces using flow cytometry.
Key Benefits
A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells.
A prototype has been developed showing proof -of-concept via the ability to determine mechanical...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Rong Ma, Khalid Salaita
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Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application
Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations.
Key Benefits
Tunable oligos increase specificity and cooperative binding to the disease target of interest.
Distinguishes between cis- and trans mutations.
Identifies different strains of...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt
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Assays for Labeling and Evaluating Lysine Methylation
Application
A life science tool for evaluating protein lysine methylation for drug discovery and disease research.
Key Benefits
Highly specific labeling method for post-translational methylated lysine.
Potential to improve the understanding of protein lysine methylation and help develop new drugs to block its interactions across several disease...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Monika Raj, Ogonna Nwajiobi
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Real-Time RT-PCR Assay for SARS-CoV-2
Application
Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Two viral targets to confirm detection in a single sample.
Does not involve the performance of multiple reactions as are required for the majority of published assays.
May be performed using several different...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jesse Waggoner
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Assay to Measure Cell Traction Forces for High Throughput Drug Screening and Mechanical Phenotyping
Application
Mechanically induced catalytic amplification reaction (MCR) as an assay for high throughput screening of drugs which target cellular mechanics and mechanical phenotyping of live cells.
Key Benefits
Adaptable for high throughput screening of drugs that impair cell mechanics.
Enables characterization of different cells types based on...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Pui Yan Ma, Khalid Salaita
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Tool for Measuring Cell Purity and Quality Control of Stem Cell-based Products
Application
Cell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development.
Key Benefits
Nanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic.
Technology is potentially more sensitive method compared to current methods.
Market...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Chunhui Xu, Shuming Nie, Ximei Qian, Jingjia Han
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Ebola Specific Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assay
ApplicationA cell based assay to quantify the titer of circulating Ebola glycoprotein (GP) antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC).Key BenefitsSpecific for detection of ADCC activity of Ebola virus antibodies or antisera.Applicable to all pathogenic strains of Ebola virus.Ebola GP-specific stable reporter cells eliminate...
Published: 2/13/2025
Updated: 7/15/2022
Inventor(s): Paul Spearman, Karnail Singh, Xuemin Chen
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Protein Phosphatase 2A Demethylase Protein and DNA Sequences
Applications Can be used in assays to search for drugs that modulate protein phosphatase 2A (PP2A) methylesterase activity or to make recombinant protein to be used in assays. Such derivatives have potential application as anti-cancer and Alzheimer's treatment drugs. Technical Summary Protein phosphatase 2A (PP2A) is involved in the regulation of a...
Published: 2/13/2025
Updated: 2/18/2016
Inventor(s): David Pallas, Xian Xing Du
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Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application
A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated.
Key Benefits
Potent (sub-nM range), non-peptidic, non-nucleosidic compounds.
Robust, cell-based, high-throughput screening assay.
Technical Summary
Vaccination serves...
Published: 2/13/2025
Updated: 2/18/2016
Inventor(s): Richard Plemper, James Snyder, Aiming Sun
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