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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application
Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time.
Key Benefits
Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva.
Requires few reagents and no expensive equipment.
Limit of detection on par with PCR and rapid readout.
Enables...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Selma Piranej, Khalid Salaita
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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application
Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow.
Key Benefits
Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear.
Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Liquid-hydrogel Hybrid Microfluidic Device
Application
Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment.
Key Benefits
Fast determination of drug sensitivity.
Long-term continuous cell-fate tracking.
Time-lapse analysis of cell proliferation.
Cell community analysis: intra-species interactions, inter-species interactions.
Market...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Kyle Allison, Xin Fang, Devina Puri
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Molecular Probe that Records Mechanical Information Produced by Living Cells
Application
A molecular probe that stores and integrates short-lived cellular mechanical events over time.
Key Benefits
Quantitative method of measuring short-lived interactions between cells.
Ideal for immunology-based assays
Fluorescence-based and amenable as a drug screening research tool.
Market Summary
Studying the interplay between mechanical...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Khalid Salaita, Rong Ma
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Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Ichiro Matsumura
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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Autonomic Formation of Wireless Mesh Networks (WMN)
Application
Autonomical control of the formation of WMNs to enable node density control, frequency diversity and cooperative, multi-domain software-defined networking (SDN) on large-scale wireless mesh networks.
Key Benefits
Enhanced capacity of wireless mesh networks.
Robust to changes in nodes (new nodes going up, old nodes going down, etc.).
Enables...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Sergio Luis Dias Lima Gramacho, Avani Wildani
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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Xiulei Mo, Haian Fu
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