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Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application
A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies.
Key Benefits
Determines immunotherapy success in patients.
CAR cells can be tested before putting it back in the patients.
Simple diagnostic with readout in 30 minutes compared to 2-3 days.
Market Summary
Lymphoblastic leukemia is one of the most...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Anna Kellner, Khalid Salaita, Curtis Henry
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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RSV Vaccine for Infants and Children
Application
Vaccine for Respiratory Syncytial Virus (RSV) in infants and children.
Key Benefits
A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants.
Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease.
Potential to...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Larry Anderson, Binh Ha, Heying Sun
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Central Line-Associated Bloodstream Infection (CLABSI) Prediction Model
Application
A predictive model of central line-association bloodstream infection (CLABSI).
Key Benefits
Specifically designed to improved predictive analysis of patients who are at risk for CLABSI.
Scored higher predictive values on average than similar predictive modeling without the hypotheses driven approach (Bidirectional LSTM with...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Azade Tabaie, Rishikesan (Rishi) Kamaleswaran, Evan Orenstein
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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Engineered Biomaterials for Vascular Grafts
Application
A biomaterial to create grafts for treating babies with congenital heart diseases.
Key Benefits
A biocompatible material that can be used to reroute blood within the body.
Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions.
Potential to be used in other cardiovascular...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
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Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application
Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy.
Key Benefits
A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen
The model can also be incorporated into future therapeutic...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): William Hu, Sumit Verma
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3D Model for Analysis and Treatment Planning of Vascular Disease
Application
A patient-specific, 3D model of pulmonary atresia for surgical planning.
Key Benefits
Patient-specific model.
Allows for accurate surgical planning.
Enables new anastomosis procedure.
Market Summary
Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
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Parent Training Curriculum to Manage Food Selectivity in Children with Autism
Application
Parent-mediated intervention, titled the Autism Managing Eating Aversions and Limited variety (MEAL) Plan, to reduce mealtime disruptive behavior and expand dietary diversity in young children with autism spectrum disorders.
Key Benefits
Hands-on parent training based intervention.
Reduces parental stress while developing a child’s...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): William Sharp, Teresa (T.) Burrell, Rashelle Berry
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Parent-Rated Anxiety Scale for Autism Spectrum Disorder (PRAS-ASD)
ApplicationScale/survey instrument for measuring anxiety in children with autism based upon a parent report.Key BenefitsIncludes 25-item measure for anxiety.Tested in a large-scale survey and clinical setting.Market SummaryAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behavior....
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Lawrence Scahill, Luc Lecavalier, Michael Aman, Karen Bearss
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