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Assessment of Tumor Response to Treatment Using Level Set Clustering in PET Images
Application
Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm.
Key Benefits
Robust to noise and outliers and can tolerate imperfections in data acquisition.
Could be applicable to many other imaging modalities in radiation therapy.
More accurately...
Published: 2/13/2025
Updated: 2/13/2025
Inventor(s): Timothy Fox, Eduard Schreibmann
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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application
VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML).
Key Benefits
Unique dual-action functionality as a microtubule and MDM2 inhibitor.
Successful inhibition of MDM2, an oncogene...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
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Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application
Protein-based therapeutics for the treatment of IgG-mediated diseases.
Key Benefits
A new class of endoglycosidases for the treatment of IgG-mediated diseases.
Four novel compounds have been developed that exhibited robust in vitro activity.
Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
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Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application
A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies.
Key Benefits
Determines immunotherapy success in patients.
CAR cells can be tested before putting it back in the patients.
Simple diagnostic with readout in 30 minutes compared to 2-3 days.
Market Summary
Lymphoblastic leukemia is one of the most...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Anna Kellner, Khalid Salaita, Curtis Henry
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application
Assist in the diagnosis of hematologic disorders of bone marrow.
Key Benefits
Automated machine learning approach for performing bone marrow differential counts that accounts for all viable cells on the smear.
Preliminary data generated by a prototype shows the system is fast and demonstrates precision compared to manual counting.
Potential...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): David Jaye, Lee Cooper, Joshua Lewis, David Gutman
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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Khalid Salaita, Radhika Sharma
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Indolium 1 for Advanced Melanoma Treatment
Application
A small molecule compound for the treatment of melanoma.
Key Benefits
Novel small molecule compound for the treatment of resistant melanoma.
Well tolerated in vivo.
Market Summary
Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Jack Arbiser
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Artificial Neural Network for Prediction of Clinical Outcomes
Application
A machine learning model to predict the need for ventriculoperitoneal shunt after posterior fossa tumor resection.
Key Benefits
Highly accurate prediction of post-surgical complications.
Reducing healthcare costs by predicting prognoses and increasing efficiency of post-surgical treatment.
Market Summary
Neurosurgical procedures...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Kimberly Hoang, Ali Alawieh, David Bray
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Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application
Immunotherapy for HER2+ and triple-negative breast cancer.
Key Benefits
Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers.
Prepared outside of the body and then administered to patients.
Preclinical data indicate treatment decreases tumor growth and improves...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
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