12 Results

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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells Application Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Data generated by a prototype shows the system is fast and demonstrates precision compared to manual... Published: 2/13/2025      Updated: 8/5/2024      Inventor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan

Myosoft: Automated Muscle Histology Analysis Application Software to automatically measure muscle fiber types and sizes. Key Benefits Accurately identify and characterize different muscle fiber types within a sample. Market Summary Despite generations of technological advancements in disease interpretation and testing technologies, accurate diagnosis of myopathy remains a challenge. Myopathy,... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Hyojung Choo, H. Criss Hartzell, Jr., Lucas Encarnacion-Rivera, Steven Foltz

Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA) Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): William Hu, Sumit Verma

Dual Mobility Femur Prosthetic to Reduce Post-Operative Hip Dislocation Application A new design of a modular hip implant with a rotational proximal junction in the femoral stem to minimize post-operative hip dislocation. Benefits Rotating femoral component alleviates torsional strain on implant, a primary cause of implant impingement and failure. Market Summary Peri-prosthetic hip dislocation is the number one... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): George Guild, III

Collagen-Mimetic Nanosheets Application Two-dimensional sheets composed of collagen-mimetic peptides on the nanoscale that are highly-ordered and self-assembling. Key Benefits Thermal stability, sheet thickness, and sheet dimensions can be controlled through the peptide sequence and preparative conditions. Market Summary Collagens are used in a number of consumer and biomedical... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Vincent Conticello, Tao Jiang

Small Molecule Therapeutic for Regeneration of Cartilage ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Scott Boden, Sreedhara Sangadala

Repurposed Small Molecules that Promote Osteogenesis Application Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Scott Boden, Sreedhara Sangadala

Surgical Device for Eyelid Ptosis Correction ApplicationSurgical device to perform clamping, incision, and closure for correcting eyelid ptosis.Key BenefitsSimplifies the Müller muscle resection that decreases surgical procedure time.Eliminates the risk of cutting sutures that cause dehiscence and improves the final appearance.Market SummaryPtosis (drooping upper eyelids) is a common condition... Published: 2/13/2025      Updated: 7/15/2022      Inventor(s): Denise Kim, Jacquelyn Borinski, Andrew Kolpitcke, Mohamad Ali Naja, Drew Padilla

Novel Bone Forming Compound for Use in Spinal Fusion Device Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Commercially available small... Published: 2/13/2025      Updated: 2/18/2016      Inventor(s): Scott Boden, Sreedhara Sangadala

Noggin Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics... Published: 2/13/2025      Updated: 2/18/2016      Inventor(s): Scott Boden, Sreedhara Sangadala

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