|
Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application
Protein-based therapeutics for the treatment of IgG-mediated diseases.
Key Benefits
A new class of endoglycosidases for the treatment of IgG-mediated diseases.
Four novel compounds have been developed that exhibited robust in vitro activity.
Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
|
|
Vital Sign Trajectory Algorithm
Application
A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients.
Key Benefits
An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis.
Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Sivasubramanium (Siva) Bhavani
|
|
Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application
Immunotherapy for HER2+ and triple-negative breast cancer.
Key Benefits
Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers.
Prepared outside of the body and then administered to patients.
Preclinical data indicate treatment decreases tumor growth and improves...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
|
|
MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Rama Rao Amara, Sailaja Gangadhara
|
|
Total Ankle Arthroplasty Design
Application
An intra-articular alignment guide for ankle replacement system to treat ankle arthritis.
Key Benefits
Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement.
More convenient to use compared to Inbone II frame and foot holder to find the correct alignment.
Market Summary
Approximately...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Rishin Kadakia
|
|
Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
|
|
Photocaged Cytokines for Cancer Immunotherapy
Application
Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy.
Key Benefits
Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity.
Prolonged circulation means less frequent dosing is required.
Biased activity towards CD8+ T-cells...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
|
|
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application
Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells.
Key Benefits
First in class, targeted immunotherapy for patients presented with KRASG12V mutation.
Attenuates immune suppression associated with KRASG12V-positive cancers.
Market Summary
The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Haian Fu, Cong Tang, Xiulei Mo
|
|
Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Hyunsuk Shim, Yoon Hyeun Oum
|
|
Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application
Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population.
Key Benefits
Significantly improved protective immunity of vaccine in the aged.
More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Elena Vassilieva, Richard Compans
|
