36 Results

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Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,... Published: 2/13/2025      Updated: 8/5/2024      Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos

Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Lawrence Boise, Katelyn Ponder

Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Vincent Conticello, Andrea Merg, Gavin Touponse

Photocaged Cytokines for Cancer Immunotherapy Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do

KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Haian Fu, Cong Tang, Xiulei Mo

Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Ichiro Matsumura

Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Steven Knutson, Jennifer Heemstra

Cas9 Controlled Gene Activation Application Flexible system using Cas9 to modulate gene expression. Key Benefits Edits genes by cleaving DNA as well as inhibiting transcription. No need to transfect cells with additional Cas9. Market Summary The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): David Weiss, Hannah Ratner

Strategy to Identify miRNAs for Disease Diagnosis Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Wenming Li

DNAzyme Nanoparticles for the Cleavage of RNA Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists... Published: 2/13/2025      Updated: 4/7/2023      Inventor(s): Jessica Petree, Kevin Yehl, Khalid Salaita

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