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Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application
Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations.
Key Benefits
Tunable oligos increase specificity and cooperative binding to the disease target of interest.
Distinguishes between cis- and trans mutations.
Identifies different strains of...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt
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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application
Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time.
Key Benefits
Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva.
Requires few reagents and no expensive equipment.
Limit of detection on par with PCR and rapid readout.
Enables...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Selma Piranej, Khalid Salaita
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Mobile Phone Diagnostic for COVID-19
Application
Diagnostic and automatic surveillance to identify COVID-19 via smartphone in real-time.
Key Benefits
Provides real-time, rapid results.
Autonomous process.
Device does not require RNA isolation or amplification for viral detection.
Market Summary
Coronavirus (COVID-19) is an infectious disease that causes severe acute respiratory...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Khalid Salaita, Alisina Bazrafshan, Selma Piranej
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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Rama Rao Amara, Sailaja Gangadhara
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Improved Clinical Diagnostic Method for SARS-CoV-2 Infection
Application
A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein.
Key Benefits
A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings.
Market Summary
SARS-CoV-2 has evolved significantly since the onset of...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): John Roback, Andrew Neish, Narayanaiah Cheedarla, Hans Verkerke, Huixia Wu, William Osick, Kaleb Mclendon, Sindhu Potlapalli
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SARS-CoV-2 Subgenomic Replicon (SARS2-Rn)
Application
A series of SARS-CoV-2 sub-genomic replicons as artificial bacterial chromosomes for the screening of SARS-CoV-2 in studies such as drug discovery and inhibitors assay.
Key Benefits
Can be used at a lower biosafety level than non-artificial copies of SARS-CoV-2.
Can be used for high throughput screening and characterization of SARS-CoV-2...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Stefan Sarafianos, Shuiyun Lan
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Yongshi: A Wild Boar Peptide with Anti-Viral Activity Targeting COVID-19
Application
An antiviral cathelicidin peptide from wild boar that exhibits antiviral properties against SARS-CoV-2.
Key Benefits
Pan-coronavirus inhibitor that may be effective for all future variants.
Functions as an inhibitor of ongoing infection.
Early data suggests it is safe to use in human tissue.
Market Summary
Coronavirus disease...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Joshy Jacob, Mehul Suthar, Troy Von Beck, Nikita Mullick, Abigail Vanderheiden, Jeffrey Skolnick
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SARS-CoV-2 Neutralizing Human Monoclonal Antibodies
Application
Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics.
Key Benefits
Demonstrably neutralizing, important for therapeutic mAbs.
Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD.
Market Summary
Coronavirus (COVID-19) is an infectious...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jens Wrammert, Carl Davis, Mehul Suthar, Robert Kauffman
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Combination of Tetrahydrobiopterin and Arginine/ ± Arginase Inhibitors for the Treatment of COVID-19
Application
A novel drug combination to address acute arginine/BH4 dysregulation that develops with COVID-19 and MIS-C infection.
Key Benefits
Potential to improve outcomes of those infected with COVID-19 with few side effects.
Repurposing opportunity with the combination of two approved drugs (tetrahydrobiopterin and arginine).
Addresses...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Claudia Morris, Lou Ann Brown
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Real-Time RT-PCR Assay for SARS-CoV-2
Application
Triplex, internally-controlled real-time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Two viral targets to confirm detection in a single sample.
Does not involve the performance of multiple reactions as are required for the majority of published assays.
May be performed using several different...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jesse Waggoner
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