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Automated Software to Quantify Breast Arterial Calcifications from Mammograms
Application
Deep learning software for the automated detection and quantification of breast arterial calcifications in screening mammograms.
Key Benefits
Optimized image segmentation accuracy with improved generalizability towards mammograms with and without BAC presence.
Robust ability to quantitate narrow or heavy BAC and/or partial depositions...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Aisha Urooj Khan, Theodorus Dapamede
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Multimodal Identification of Atrial Fibrillation Recurrence Sites
Application
Identifies areas of interest associated with atrial fibrillation recurrences.
Key Benefits
Identifies sites associated with recurrences for AF patients.
Predict AF recurrence risk in patients’ post-catheter ablation.
Development of prediction model by extracting features from the surface of interest (SOI).
Market Summary
Atrial...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Abhishek Midya, Anant Madabhushi, Golnoush Asaeikheybari, Mina K. Chung, Amogh Hiremath, Moore Benjamin Shoemaker, Majd A. El-Harasis, John Barnard, Rod S. Passman
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Drug Screening System for Cardioprotection
Application
A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity.
Key Benefits
A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol.
Preliminary data in the laboratory show the system is clinically relevant...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Khalid Salaita, Radhika Sharma
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System for Assessing Health Severity and Predicting Readmissions
Application
A smartphone-based system for monitoring patients to identify and prevent severe cardiac events.
Key Benefits
A remote monitoring system that uses smartphone data to accurately predict a user’s risk for a severe cardiac event (e.g., heart attack).
Tracks the user's movement, location, and physical activity to calculate FDA-accepted...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Gari Clifford, Amit J. Shah, Ayse Cakmak, Erik Reinertsen
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ONC201 for the Treatment of Vascular Aneurysms
Application
A repurposed therapeutic for the preventative and treatment of aneurysms.
Key Benefits
A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm.
The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Alejandra Maria San Martin
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Engineered Biomaterials for Vascular Grafts
Application
A biomaterial to create grafts for treating babies with congenital heart diseases.
Key Benefits
A biocompatible material that can be used to reroute blood within the body.
Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions.
Potential to be used in other cardiovascular...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
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Automated Breast Arterial Calcifications Segmentation and Quantification on Mammograms Using Deep Learning
Application
Software for the quantification of breast arterial calcifications on routine mammograms to be used for risk stratification for cardiovascular outcomes.
Key Benefits
Optimized image segmentation accuracy with reduced software complexity.
Integrated calcium scoring.
Screens patients who would not normally be indicated for cardiac...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Xiaoyuan Guo
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Torque Device for Procedures Using Guidewire
Application
Torque device for one-handed manipulation of guidewire during endovascular, interventional and catheterization lab procedures.
Key Benefits
Enables single-person, one-handed use.
Prevents ejection of guidewire during torque device removal.
Allows placement of torque device anywhere on the wire.
Market Summary
Interventional procedures,...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Yuriy Aranbayev, William Jordan, Jr.
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3D Model for Analysis and Treatment Planning of Vascular Disease
Application
A patient-specific, 3D model of pulmonary atresia for surgical planning.
Key Benefits
Patient-specific model.
Allows for accurate surgical planning.
Enables new anastomosis procedure.
Market Summary
Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
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