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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Rama Rao Amara, Sailaja Gangadhara
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Vaccines and Antibody Therapeutics for HPV-related Cancers
Application
Treatment and prevention of HPV-induced malignancies.
Key Benefits
Identification of a protein expressed in a large number of HPV-induced cancers.
Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells.
The antibodies can be used to develop new treatments and vaccines...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Rafi Ahmed, Andreas Wieland
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Photocaged Cytokines for Cancer Immunotherapy
Application
Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy.
Key Benefits
Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity.
Prolonged circulation means less frequent dosing is required.
Biased activity towards CD8+ T-cells...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
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Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application
Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax.
Key Benefits
Co-therapy increases MM sensitivity to venetoclax treatment.
Identifies patients who will respond to venetoclax therapy.
Market Summary
Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Malathy (Mala) Shanmugam, Richa Bajpai
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A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application
A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients.
Key Benefits
Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients.
A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients.
Market...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Malathy (Mala) Shanmugam, Richa Bajpai
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Frog Skin Peptides for Treatment of Human Influenza Viruses
Application
A therapeutic peptide that treats Influenza A virus
Key Benefits
New method of action compared to antiviral drugs currently in use.
Therapeutic peptide is virucidal against drug resistant strains.
Market Summary
Worldwide seasonal influenza epidemics can impact 5 – 15% of the population. The occurrence of vaccine mismatch...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Joshy Jacob, David Holthausen, Song Lee, Sanil George
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Bacteria Strain in Probiotic Formulation for Weight Control
Application
Bacterial strain from Lactococcus lactis as a potential dietary supplement or therapeutic to help weight control and control gut inflammation.
Key Benefits
Provides anti-inflammatory effects in the intestine.
Improves weight control and protects against fatty liver disease in mice fed a high fat and high sugar Western-style diet.
This...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Rheinallt M. Jones, Trevor Darby
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IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
Application
Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.
Key Benefits
Preserves the immunosuppressive function of MSCs following thawing.
Improves effectiveness of transplanted MSCs following cryopreservation.
Market Summary
Mesenchymal...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
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Repurposed Kinase Inhibitor for Treatment of Multidrug Resistant Tuberculosis
ApplicationProtein tyrosine kinase inhibitor (imatinib) used as a treatment to prevent multiple drug-resistant tuberculosis lethality and latent reactivation.Key BenefitsEffective against drug resistant strains of tuberculosis.May be used in combination with current first-line treatments of TB.Market SummaryTuberculosis (TB) is a chronic infectious...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Daniel Kalman
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SpineGuide: Magnetic Resonance Imaging-Compatible Spinal Therapeutics Delivery System
ApplicationMRI-compatible device that enables precise delivery of therapeutic or cells to specific locations in the spinal cord. Key BenefitsCompatible with real-time MRI imaging systems allowing for the targeting and delivery of therapies concurrent with imaging. Can precisely guide and deliver a multitude of therapies (small molecules, biologics or...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Nicholas Boulis, John Oshinski, Jason Lamanna, Cody Anderson
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