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EF-Tu Targeting Antibody for Infection Treatment
Application
Therapeutic monoclonal antibodies directed to Elongation Factor-Tu (EF-Tu) for the treatment of infections.
Key Benefits
An antibody that targets the protein EF-Tu, which is present on many types of bacteria involved in life-threatening infections.
A research-grade antibody has been developed with animal data showing the ability to...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Joanna Goldberg, Dina Moustafa
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SARS-CoV-2 Neutralizing Human Monoclonal Antibodies
Application
Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics.
Key Benefits
Demonstrably neutralizing, important for therapeutic mAbs.
Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD.
Market Summary
Coronavirus (COVID-19) is an infectious...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jens Wrammert, Carl Davis, Mehul Suthar, Robert Kauffman
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BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
Application
ELISA
Western Blot
Immunohistochemistry
Specficity
HIV-1 BG505 Env protein (clone name: YRK01, YRK02).
Subtype
Monoclonal antibody.
Immunogen
HIV-1 BG505 SOSIP Env trimer.
Technical Summary
HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Cynthia Derdeyn, Tysheena Charles
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Antibody Therapy for Varicella Zoster Virus
Application
Human monoclonal antibodies for the treatment of varicella zoster virus (VZV).
Key Benefits
Human monoclonal antibodies can limit the spread of VZV.
gH-specific antibodies are complement-independent.
Market Summary
Varicella Zoster Virus (VZV) causes varicella, more commonly known as chickenpox. Once the illness resolves, the virus...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Rafi Ahmed, Nicole Sullivan
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Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application
Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients.
Key Benefits
Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
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Antibodies for Zika and Dengue Viruses
Applications
ELISA
Western Blot
Immunohistochemistry
Specificity
Human monoclonal
Technical Summary
Zika Virus (ZIKV) is a mosquito borne filovirus responsible for a 2016-2017 epidemic in North and South America. ZIKV nonstructural protein 1 (NS1) is a pathogenicity factor implicated in virus replication, host interaction and immune invasion....
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Jens Wrammert, Mark Mulligan
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Antibodies for α-Synuclein Cleavage by Asparagine Endopeptidase (AEP) and Activated AEP
Application
ELISA
Western Blot
Immunohistochemistry
Subtype
Rabbit polyclonal
Technical Summary
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. It is characterized by the loss of predominately dopamine-producing neurons in a specific area of the brain called substantia nigra. α-Synuclein...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Keqiang Ye
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Glycoprotein Tetramer for Identifying Antigen-specific B Cells
Application
Ectodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.
Key Benefits
Viral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.
Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.
Market Summary
Hepatitis...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Arash Grakoui, Joseph Marcotrigiano
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Promising Antibodies Target Virus Glycoprotein for Vaccination and Therapy
ApplicationAntibodies that bind and neutralize Ebola virus glycoprotein (GP) for use in vaccination or treatment of Ebola virus disease.Key BenefitsHigher binding affinity for Ebola virus GP than closest competitor.Can be used prophylactically or for treatment of Ebola virus disease.Market SummaryThe Ebola virus is an RNA virus with a membrane composed...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Rafi Ahmed, Carl Davis, Erica Ollmann Saphire
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Sodium-Hydrogen Antiporter 3 (NHE3) Antibody
Applications
Western Blot
Immunoprecipitation
Specificity
Human
Subtype
Rabbit Polyclonal
Technical Summary
Sodium-hydrogen antiporter 3 (NHE3) is found in the nephron of the kidney and in the apical membrane of enterocytes of the intestine. Intestinal epithelial cells express multiple forms of NHEs among which, type 3 is the primary brush-border...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Chang-Hyon Chris Yun
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