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Mouse Model for Specific Proteomic Labeling
Application
Proteomic labeling (labeling of proteins).
Key Benefits
Method can be used to express TurboID in any cell type.
The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system.
Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms.
Can...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Srikant Rangaraju, Nicholas (Nick) Seyfried, Sruti Rayaprolu
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A GALT-null Rat Model for Studies of Classic Galactosemia
Application
Pre-clinical rodent model to study classic galactosemia disease.
Key Benefits
Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points.
Study the relationship between galactose metabolite levels in blood and other tissues.
Study the impact of rigorous galactose restriction...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Judith Fridovich-Keil
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Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application
Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors.
Key Benefits
Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species.
The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 2/13/2025
Updated: 8/5/2024
Inventor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
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Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application
Improved study of neurodegenerative diseases on mice.
Key Benefits
Ability to study neuromelanin’s association with neurodegenerative diseases with mice.
Researchers can analyze overexpression of tyrosinase on specific cell types.
Market Summary
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): David Weinshenker, Alexa Iannitelli
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3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Nigel Pedersen, Lauren Aiani
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ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Erwin Van Meir
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Human Osteopontin Knock-in Mouse Line
ApplicationMouse lines expressing isoforms a, b, and c of the Human Osteopontin (OPN) protein for cancer research.Technical SummaryThe murine OPN is not subject to splicing and therefore does not express different isoforms. Human cancers express splice variants. Emory researchers developed these mouse models to express each isoform independently from...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Alicia Lyle
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Cre-Lox PAR1 Conditional Knockout Mouse
Key BenefitsTissue-specific knockout mouse, allowing PAR1 to be inactivated in specific cell types in certain tissue.Inducible knockout mouse, allowing PAR1 to be temporally suppressed at a given time-point in embryonic, post-natal or adult animals.Eliminates drawbacks and side effects of traditional knockout processes that eliminate genes from the...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Stephen Traynelis
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Knock-In Mouse Model of Oculopharyngeal Muscular Dystrophy
ApplicationConditional knock-in mouse mimicking Oculopharyngeal muscular dystrophy.Technical SummaryOculopharyngeal muscular dystrophy (OPMD) is rare genetic disease caused by a mutation in the PABPN1 gene. In this mutation, the number of GCG trinucleotide repeats at the 5' end of PABPN1 are increased, which leads to an expansion of an alanine repeat...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Grace Pavlath, Anita Corbett, Katherine Vest
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3q29 Deletion Mice
Application
Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders.
Technical Summary
Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 2/13/2025
Updated: 4/7/2023
Inventor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
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